ISSN: 1323-8930Volume 74, Issue 1 (January 2025)
Review Series: T follicular helper cells and IgE
As the analysis of T follicular helper (Tfh) cells progresses, their involvement in the pathology of allergies is becoming clearer. The purpose of this review series is to elucidate the function of Tfh and follicular regulatory T (Tfr) cells as well as their relationship to IgE and allergic disease.
Dr. Koenig focuses on the cellular and molecular mechanisms underlying the long-term production of IgE and Tfh cell heterogeneity.
Dr. Cañete et al. describe the cytokines and signaling pathways involved in the regulation of IgE production and their relationship to Tfh cells. They also discuss the impacts of immunotherapy and treatment with biologics for T2 type response on Tfh cells.
Dr. Dent reviews the current literature on Tfr cells, reporting that in mouse models of allergic diseases, Tfr cells exhibit a dual role as both suppressors and helpers regarding IgE responses.
Dr. Akiyama et al. give us the details of the characteristics and differentiation pathways of human Tfh subsets, providing a comprehensive review of the roles of human Tfh cells in allergy, malignancy, and IgG4-related diseases.
