Editor’s comment: The conventional in vitro lymphocyte transformation assay (LTT) for diagnosing drug hypersensitivity reactions is limited by sensitivity. Peyer et al. (Switzerland) report a cytokine-based lymphocyte transformation test (Cyto-LTT) that quantifies drug-specific cytokine responses in T cells. The results reveal dose-dependent T cell activation in delayed drug hypersensitivity, challenging that drug allergic reaction are dose-independent. Their findings suggest that delayed drug hypersensitivity reflects graded immune activation with clinical relevance. Please also refer to Review Article by Werner J. Pichler entitled "Undressing DReSS as p-i mediated disease"

Editor’s comment: Goblet cell metaplasia is a key pathological feature of allergic asthma, but its regulatory mechanisms remain incompletely defined. Xu et al. (China) demonstrates that transcription factor EGR2 is selectively upregulated in allergic airway epithelium and functions downstream of IL-13/STAT6 signaling. Genetic and pharmacological modulation of EGR2 alters mucus production and airway hyperresponsiveness, identifying EGR2 as a critical transcriptional regulator of asthmatic epithelial remodeling.